What is the generic name for HPMC?

What is Hypromellose?

Hypromellose, also known by its generic name hydroxypropyl methylcellulose (HPMC), is a semi-synthetic, inert, viscoelastic polymer widely utilized in various products. This compound is prominently found in eye drops and serves as an excipient and controlled-release agent in oral medications.

As a food additive, hypromellose acts as an emulsifier, thickening agent, and an alternative to gelatin derived from animals. Its Codex Alimentarius code (E number) is E464, indicating its classification in food applications.

Chemistry of Hypromellose

Hypromellose appears as a slightly off-white to beige powder and can be processed into granules. It forms colloids when mixed with water. While non-toxic, this chemical is combustible and has the potential to react with oxidizing agents.

When dissolved in water, hypromellose exhibits thermal gelation properties, meaning it can congeal into a semi-flexible mass under heat. This property correlates inversely with both the concentration of the solution and the concentration of the methoxy group in the HPMC molecule.

Applications of Hypromellose

Hypromellose finds uses in a variety of sectors, such as:

• Tile adhesives
• Cement renders
• Pharmaceuticals
• Food products
• Cosmetics
• Eye drops and contact lenses

Using HPMC in Food

In the food industry, HPMC acts as a thickening, emulsifying, and suspending agent, enhancing the texture and stability of various products.

Construction Material Applications

Within the construction industry, hypromellose is utilized in admixtures such as tile adhesives and cement renders. It functions as a rheology modifier, water retention agent, and helps improve the workability of mixtures.

Ophthalmic Applications

Hypromellose solutions are also designed for ophthalmic use as a substitute for natural tears, enhancing moisture retention and providing relief in dry environments. As a vegetarian alternative to gelatin, HPMC solutions are valuable in many medical contexts.

Excipient and Tableting Ingredient

Hypromellose is employed as an excipient in tablet formation, serving as a binder and a controlled release agent, which slows down the release of active ingredients in the digestive system.

Test Methods for Hypromellose

Various testing methods evaluate properties like viscosity, degree of substitution, and moisture content to ensure quality control.

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