Hydroxypropyl Methylcellulose – Applications and Benefits

Hydroxypropyl Methylcellulose – Applications and Benefits

SidleyCel Hydroxypropyl Methylcellulose

Sidley Chemical Co.,LTD is a manufacturer of Hydroxypropyl Methylcellulose, If interesting it, please don’t hesitate contact us. : [ protected]

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SidleyCel™ Hydroxypropyl MethylCellulose product is a non-ionic cellulose ether made through a series of chemical processes, with the natural polymer cellulose as the raw material. The product is a non-ionic cellulose ether in the shape of white powder, odorless and tasteless. In cold water, it swells into a clear or slightly turbid colloidal solution. It has thickening, adhesion, dispersion, emulsification, film-formation, suspension, gelation, surface activity, water retention, providing protective colloids and other properties. Hydroxypropyl methylcellulose (HPMC) can be used in building materials, synthetic resin, ceramic industry, medicine, food, textile, agriculture, daily chemicals and other industries.

Hydroxypropyl Methyl Cellulose products have different proportions of Methoxy and Hydroxypropyl, thus affecting the thermal gelation temperature of Hydroxypropyl Methyl Cellulose, and other property items.

In processed foods, Hydroxypropyl MethylCellulose has many excellent properties. According to the thermal gelation, film-forming, thickening and other properties it can be applied to different foods so as to enhance the taste of food. The formulation of bread contains 1% of Hydroxypropyl Methylcellulose, and gelation occurs in contact with hot oil. In this way, a protective layer can be formed at the edge of the frying food, greatly reducing the absorption of fat.

Application of SidleyCel™ Hydroxypropyl Methyl Cellulose in the Construction Industry: As the water-retaining agent and retarder of cement mortar, it enables the mortar to have pumping property. In plaster slurry, gypsum materials, putty powder or other building materials, it acts as a binder and helps to improve the spreadability and prolong the operating time.

Application of Hydroxypropyl Methyl Cellulose in PVC (Polrvinyl Chloride): In the production of PVC, it can act as a dispersing agent, the main additive in the preparation of PVC by suspension polymerization.

Applications

Description/Benefits

Medicine, Food Personal Industrial

As the product is non-ionic, and in the preparation process can be effectively purified by washing with hot water, it has a very low ash content. Hydroxypropyl Methylcellulose products can fully meet the standards for use of medicine, food, and personal care products.

Application Guide for PVC Industry

In the polymerization process of PVC suspension polymerization system, The use of Hydroxypropyl Methylcellulose as a dispersant can improve suspension dispersion properties, can also improve the particle morphology, and enhance the absorption performance on plasticizers.

Application Guide for Building Material Industry

Hydroxypropyl Methylcellulose has high water-holding capacity, can extend the working time of mortar, improve work efficiency and is good for the mortar to produce high mechanical strength during solidification.

Document  Library

Effects of Hydroxypropyl Methyl Cellulose(HPMC) in Dry Mortar in Construction:Hydroxypropyl Methyl Cellulose has higher adhesion on mortar construction than methyl cellulose (MC). read more Solubility of Hydroxypropyl Methylcellulose (HPMC):Because Hydroxypropyl Methylcellulose (HPMC) does not dissolve in hot water, in the initial stage, Hydroxypropyl Methylcellulose can be evenly dispersed in hot water, and then it rapidly dissolves when cooled.read more  Application of Hydroxypropyl Methylcellulose in Food and Cosmetic Industries:Hydroxypropyl Methylcellulose can be added to fruit syrup and ice to make the taste better.read more Introduce Hydroxypropyl MethylCellulose (HPMC) :Besides, Hydroxypropyl Methylcellulose(HPMC) has thickening capacity, salt tolerance, low ash content, pH stability, water-retaining property, dimensional stability, excellent film-forming ability, extensive resistance to enzymes, dispersibility and cohesiveness. read more Properties of  HPMC (Hydroxypropyl MethylCellulose):Hydroxypropyl MethylCellulose is a non-ionic cellulose ether, in the appearance of white powder, odorless and tasteless. It is soluble in water, most polar organic solvents, and the appropriate proportion of ethanol/water, propanol /water and dichloroethane, but insoluble in diethyl ether, acetone, and anhydrous alcohol. read more What is Hydroxypropyl methyl cellulose ?Hydroxypropyl methyl cellulose (HPMC) is a polymer used for multiple applications in fields such as construction and ophthalmology. It is also known as hypromellose, which is the international, non-proprietary name (INN) for this substance. The name is not patented by any drug company, and can be used without fear of trademark or copyright infringement. HPMC is a solid substance at room temperature and is typically beige in color.One of the most important properties of hydroxypropyl methyl cellulose is that, in a water-based solution, it does not have a gelation property when heated. Instead of precipitating out as methylcellulose does, it causes the entire solution to congeal into a semi-flexible mass that can no longer flow. The more HPMC that is present, the lower the critical temperature needed to achieve this effect. read more What is hydroxypropyl methylcellulose?Hydroxypropyl methylcellulose is a semisynthetic polymer used for multiple applications including as an ophthalmic lubricant, as an excipient and controlled-delivery constituent in oral medicaments found in a range of commercial products. read more High-Molecular-Weight Hydroxypropylmethylcellulose Taken with or between Meals Is Hypocholesterolemic in Adult MenHydroxypropylmethylcellulose (HPMC) is a food gum that shares certain characteristics, such as high viscosity, with soluble fibers. In this trial, the safety and cholesterol-lowering efficacy of HPMC consumed with and between meals was evaluated in free-living male volunteers with mild-to-moderate hypercholesterolemia. Read more HYDROXYPROPYLMETHYL CELLULOSEPrepared at the 74th JECFA () and published in FAO JECFA Monographs 11 (), superseding the specifications prepared at the 63rd JECFA (), published in the Combined Compendium of Food Additive Specifications, FAO JECFA Monographs 1 (). A group ADI ”not specified” for modified celluloses (ethyl cellulose, ethyl hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, methyl ethyl cellulose, and sodium carboxymethyl cellulose) was established at the 35th JECFA ().more High-Viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose and Insulin ResponsesHigh-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation was to assess the influence of HV-HPMC on postprandial glucose and insulin responses in overweight and obese men and women. more The rheological properties of isolated hydroxypropyl methylcellulose tissue engineering matricesCellulose ethers are water-soluble polymers derived from cellulose, the most abundant polymer in nature. They have been used for a long time in pharmaceutical and food industries, due to their ability to behave as emulsifiers, colloidal stabilizers, and flow controllers, but also owing to their non-toxic nature. Moreover, cellulose ethers exhibit appropriate biological properties which make them suitable for biomedical applications .Hydroxypropylmethylcellulose (HPMC) is a cellulose derivative polymer. HPMC is a methylcellulose modified with a small amount of propylene glycol ether groups attached to the anhydroglucose of the cellulose .moreHydroxypropyl methyl cellulose(CAS No. -65-3)

HPMC vs methylcellulose, what are their differences? Hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) are both widely used in the pharmaceutical and food industries as hydrophilic polymers. These polymers have similar structures but different properties that make them suitable for different applications.

First, let's understand these two chemicals before comparing their differences:

What is HPMC?

HPMC is a semi-synthetic, water-soluble polymer that is derived from cellulose. It is obtained by modifying natural cellulose with propylene oxide and methyl chloride. HPMC is a versatile polymer that has a wide range of applications in the pharmaceutical, food, and cosmetic industries. It is used as a thickener, emulsifier, binder, and stabilizer in various formulations.

What is Methylcellulose?

Methylcellulose (MC) is also a water-soluble polymer that is derived from cellulose. It is obtained by reacting cellulose with methyl chloride. Like HPMC, MC is used as a thickener, emulsifier, and stabilizer in various applications. However, MC is not as versatile as HPMC and is mainly used in the food industry as a food additive.

HPMC vs Methylcellulose: What Are the Differences?

Molecular Weight

One of the primary differences between HPMC and methylcellulose is their molecular weight. HPMC has a higher molecular weight than methylcellulose, which means it can form more extensive and stronger gels. Therefore, HPMC is often used in applications where high viscosity and gel strength are required, such as in pharmaceutical tablet coatings and sustained-release formulations.

Methylcellulose has a lower molecular weight, which makes it more soluble and dispersible in water. As a result, it is often used as a thickening agent in food and personal care products, such as shampoos and lotions.

Degree of Substitution

Another significant difference between HPMC and methylcellulose is their degree of substitution (DS). The DS refers to the number of hydroxyl groups on the cellulose chain that have been substituted with a particular functional group, such as methyl or hydroxypropyl. The DS affects the water solubility and gelation properties of the cellulose derivative.

HPMC typically has a higher DS than methylcellulose, which results in higher water solubility and better gelation properties. This makes HPMC a more suitable option for applications that require strong gels, such as in the production of sustained-release drug formulations. Methylcellulose, on the other hand, has a lower DS, which makes it more water-soluble and less prone to gelation. So, it’s a more suitable option for applications that require a thickening agent, such as in the production of sauces, soups, and salad dressings.

Want more information on Hydroxypropyl Methyl Cellulose (HPMC)? Feel free to contact us.

Applications

While both HPMC and methylcellulose have similar properties, they are often used for different applications. HPMC is widely used in the pharmaceutical industry as a tablet coating material, binder, and sustained-release agent. It is also used in construction as a water retention agent and in personal care products as a thickener and stabilizer.

Methylcellulose is commonly used as a food thickener and emulsifier in the food industry.  It is also used in personal care products, such as shampoos and lotions, as a thickener and stabilizer.

HPMC vs Methylcellulose: Which One is Better

HPMC and MC both have their own advantages and disadvantages, and we can compare them to choose according to our needs and preferences:

Pros of HPMC:

Has a higher degree of substitution than methylcellulose, making it more hydrophilic and thus more suitable for certain applications

Has better film-forming properties than methylcellulose, making it a popular choice for tablet coatings in the pharmaceutical industry

Offers good thermal stability, which makes it useful in high-temperature applications

Generally more cost-effective than methylcellulose

Cons of HPMC

Can be more difficult to dissolve in water than methylcellulose

May not be suitable for all applications due to its synthetic nature

Can have a slight impact on the taste and texture of food products due to its high viscosity

Pros of Methylcellulose:

Generally easier to dissolve in water than HPMC

A natural, plant-based polymer that may be preferred by some consumers and producers

Has a lower viscosity than HPMC, making it more suitable for certain applications where a thinner consistency is desired

Is a good source of dietary fiber, which can provide health benefits in certain applications

Cons of Methylcellulose:

May not have the same film-forming properties as HPMC, which can limit its use in certain pharmaceutical applications

Can have lower thermal stability than HPMC, which can limit its use in high-temperature applications

May be more expensive than HPMC in some cases

Conclusion

HPMC and MC are both widely used hydrophilic polymers with similar structures but different properties. HPMC is more versatile than MC and is used in a wider range of applications in the pharmaceutical, food, and cosmetic industries. It has better water solubility, stability, film-forming properties, and viscosity than MC. MC is mainly used as a thickener and stabilizer in food applications, and as a binder and disintegrant in tablet formulations in the pharmaceutical industry. 

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