Comparison of ivermectin and extended-release ...
Comparison of Ivermectin and Extended-Release Eprinomectin
Authors
Keywords:
cattle, fecal egg count, grazing, ostertagia, parasite, deworming, avermectin nematicides, avermectins, beef cattle, body condition, carcass composition, carcass quality, carcass weight, carcass yield, eprinomectin, faecal egg count, feedlots, fenbendazole, ivermectin, liveweight, liveweight gain, summer, parasites, helminths, helminthoses, parasitoses, nematode infections, animal parasitic nematodes
Abstract
The effect of deworming beef heifers with either ivermectin or extended-release eprinomectin on performance and carcass characteristics of stocker and feedlot cattle was assessed. Sixty Angus heifers (610 +/- 50 lb initial body weight; 277 +/- 23 kg) were blocked by body condition score and body weight, and allotted to one of two injectable deworming treatments after grazing summer pasture for 35 days: (1) ivermectin (IVM) or (2) extended-release eprinomectin (ERE). After 63 days grazing, heifers were placed in a feedlot and fed a finishing ration for 150 days. Heifers were stratified by BW within grazing treatment and assigned to receive ivermectin (dewormed; DWRM) or no treatment during processing (NO) at feedlot entry. Although fecal egg counts did not differ at treatment initiation, egg counts were significantly higher in the IVM group (5.138 eggs per gram) compared to the ERE group (0.073 EPG) at the end of the grazing period (P < 0.01). Heifers in the ERE group demonstrated greater average daily gain and body weight change (P=0.01) during the grazing period. However, there were no significant differences in feedlot performance or carcass characteristics (P ≥ 0.09) between the treatment groups. This study suggests there is potentially no benefit to deworming at feedlot arrival if cattle are effectively managed to minimize internal parasite infections during the grazing period. Despite exceptionally low levels of infection during grazing, parasites can still significantly influence performance.
A Comparative Study on the Effects of Eprinomectin and Ivermectin
A Comparative Study on the Effects of Eprinomectin and Ivermectin on Plasma Antioxidant Level and Lipid Peroxidation in Cows
BİLGİLİ A., Kart A., ÇİĞDEMİŞ Y., Hanedan B., ERDAĞ D.
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.15, no.2, pp.287-292, (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
15
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Issue:
2
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Publication Date:
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Journal Name:
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI -
Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
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Page Numbers:
pp.287-292
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Keywords:
Eprinomectin, Ivermectin, MDA, GSH, TOPICAL ENDECTOCIDE, OXIDATIVE STRESS, CATTLE, PHARMACOKINETICS, TRANSFERASE, TOXICITY, INCREASE
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Ankara University Affiliated:
Yes
Abstract
Avermectins including Ivermectin and Eprinomectin are broad-spectrum endectocides. These drugs are generally deemed to have no serious adverse effects at therapeutic ranges. Nevertheless, using avermectins in high doses in certain animal species, or at therapeutic levels in humans, can result in adverse effects primarily concerning the nervous system and other general symptoms. This study aimed to investigate the effects of Eprinomectin and Ivermectin on plasma malondialdehyde (MDA) and glutathione (GSH) levels in lactating cows. Ten Holstein breed lactating dairy cows were divided into two groups. Prior to drug administration, blood samples were collected from the jugular vein in each group at 0 hours as a control, followed by Group 1 and 2 receiving a single pour-on application of Ivermectin (0.5 mg/kg body weight) and Eprinomectin (0.5 mg/kg body weight), respectively. Blood samples were collected from the jugular vein at various time intervals (1, 4, 8, 24, 36 hours, and also on the 2nd, 3rd, 4th, 5th, 6th, 8th, 10th, 12th, 15th, 20th, and 25th days) to determine plasma MDA and GSH concentrations. Both Eprinomectin and Ivermectin treatment resulted in a transient decrease in GSH levels followed by a temporary increase (P < 0.05). No significant differences were noted in MDA levels at all sampling points post-treatment with Eprinomectin and Ivermectin compared to control samples (P > 0.05). It was concluded that both Eprinomectin and Ivermectin lead to a decrease in GSH concentrations without affecting MDA levels, which can lower the defense mechanism against oxidative stress, although the reduction was insufficient to cause lipid peroxidation.
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